Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 5,8-Difluoro-2,3-dihydrophthalazine-1,4-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Hydrazine | HCID 9321 | — |
| 반응물 | 3,6-Difluorophthalic anhydride | HCID 513918 | — |
| 반응물 | Sodium Acetate | HCID 517045 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 5,8-Difluoro-2,3-dihydrophthalazine-1,4-dione | HCID 66732009 | — |
반응 단계
To 4,7-difluoroisobenzofuran-1,3-dione (1.00 g, 5.43 mmol) and sodium acetate (0.535 g, 6.52 mmol) was added water (14 mL), acetic acid (7.15 ml, 125 mmol) and hydrazine (0.205 ml, 6.52 mmol)(slowly). A water condenser was attached and the mixture was heated to reflux for 20 hours. Cooled to RT and filtered the resulting solid. Washed with water and dried to yield 5,8-difluoro-2,3-dihydrophthalazine-1,4-dione as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07560551B2 |
| 출처 데이터셋 | uspto-grants-2009_07 |
| ORD ID | ord-5460c3ba3c4a4c8fa56cd25eccb4a0ca |
| 출처 메모 | uspto-grants-2009_07 |