HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-(hydroxymethyl)pyridine-4-carboxylate → Methyl 2-formylisonicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-(hydroxymethyl)pyridine-4-carboxylate | HCID 13276248 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 2-formylisonicotinate | HCID 19744506 | 72% |
Reaction Steps
To a solution of methyl 2-(hydroxymethyl)pyridine-4-carboxylate (30 g, 179.64 mmol) in DCM (1 L) was added MnO2 (93.77 g. 1.0778 mol) at r.t. and stirred overnight. The reaction mixture was then filtered and concentrated to afford the title compound (21.3 g, 72%). [M+H] Calc'd for C8H7NO3, 166. Found, 166.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133166B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-6c865212858146c2b7ba0698c5b715d8 |
| Source note | uspto-grants-2015_09 |