HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 90407681, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-Fluorophenylboronic acid | HCID 285645 | — |
| Reactant | HCID 90407382 | HCID 90407382 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 90407681 | HCID 90407681 | 48% |
Reaction Steps
A mixture of 2-[5-bromo-1-[2-(2-chlorophenyl)ethyl]imidazol-4-yl]pyridine-4-carbonitrile (1 eq), 4-fluorophenylboronic acid, Pd(dppf)Cl2 (0.1 eq) and Na2CO3 (2 eq, 2 M) in dioxane was refluxed overnight under N2. The reaction mixture was concentrated and purified by FCC (DCM/MeOH=20/1) to give the title compound (48%). [M+H] Calc'd for C23H16ClFN4, 403. Found, 403.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133166B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-f2af0b738cd5421eb2946fccde0c3186 |
| Source note | uspto-grants-2015_09 |