HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 90407393, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-Fluorophenylboronic acid | HCID 285645 | — |
| Reactant | HCID 90407150 | HCID 90407150 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 90407393 | HCID 90407393 | 88.6% |
Reaction Steps
A mixture of 2-[5-bromo-1-[(2-chlorophenyl)methyl]imidazol-4-yl]pyridine-4-carbonitrile (270 mg, 0.726 mmol), 4-fluorophenylboronic acid (203 mg, 1.452 mmol), Pd(dppf)Cl2 (60 mg, 0.0726 mmol) and Na2CO3 (0.3 mL, 1.452 mmol, 2 M) in dioxane (10 mL) was refluxed overnight under N2, concentrated and purified by FCC (DCM/MeOH=20/1) to give the title compound (250 mg, 88%). [M+H] Calc'd for C22H14ClFN4, 389. Found, 389.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133166B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-4d363536be87434fad9c99b2afe7667a |
| Source note | uspto-grants-2015_09 |