Potassium Carbonate → HCID 90407496, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(1H-imidazol-4-yl)pyridine-4-carboxamide (200 mg, 1.06 mmol, PREPARATION 7), methanesulfonic acid 2-(2-ethoxy-phenyl)-ethyl ester (311 mg, 1.28 mmol) and K2CO3 (294 mg, 2.13 mmol) in DMF (10 mL) was stirred overnight at 70° C., LC/MS showed the reaction was completed, purified by FCC (DCM/MeOH=20/1) to give the title compound (189 mg, 53%) as a yellow solid. [M+H] Calc'd for C19H20N4O2, 337. Found, 337.

Provenance & Evidence