Ethanol, 2,2,2-trifluoro-, 1-(4-methylbenzenesulfonate) → HCID 90407175, compound

HRID 2277553Notes

Reaction equation

HRID 2277553 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[CH:11]=[C:10]([C:12]([NH2:14])=[O:13])[CH:9]=[CH:8][N:7]=2)[N:3]=[CH:2]1.[F:15][C:16]([F:30])([F:29])[CH2:17]OS(C1C=CC(C)=CC=1)(=O)=O>>[F:15][C:16]([F:30])([F:29])[CH2:17][N:1]1[CH:5]=[C:4]([C:6]2[CH:11]=[C:10]([C:12]([NH2:14])=[O:13])[CH:9]=[CH:8][N:7]=2)[N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 67942Ethanol, 2,2,2-trifluoro-, 1-(4-methylbenzenesulfonate)HCID 178513687HCID 178513687, compound

Product 1

HCID 90407175HCID 90407175, compoundYield 60%

Procedure

The title compound was prepared in 60% yield from 2-(1H-imidazol-4-yl)pyridine-4-carboxamide (PREPARATION 7) and toluene-4-sulfonic acid 2,2,2-trifluoro-ethyl ester according to the procedure for the preparation Example 128, part A. [M+H] Calc'd for C11H9F3N4O, 271. Found, 271.

Sources & evidence

ORD record
ord-067c4500e1db488c96d44a8f24842f18
Source dataset
uspto-grants-2015_09
Patent number
US09133166B2

Reaction notes

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