[4-Fluoro-3-(2,2,2-trifluoroethoxy)phenyl]boronic acid → HCID 90407303, compound

HRID 2277564Notes

Reaction equation

HRID 2277564 reaction equation
Br[C:2]1[N:6]([CH3:7])[CH:5]=[N:4][C:3]=1[C:8]1[CH:13]=[C:12]([C:14]#[N:15])[CH:11]=[CH:10][N:9]=1.[F:16][C:17]1[CH:22]=[CH:21][C:20](B(O)O)=[CH:19][C:18]=1[O:26][CH2:27][C:28]([F:31])([F:30])[F:29]>>[F:16][C:17]1[CH:22]=[CH:21][C:20]([C:2]2[N:6]([CH3:7])[CH:5]=[N:4][C:3]=2[C:8]2[CH:13]=[C:12]([C:14]#[N:15])[CH:11]=[CH:10][N:9]=2)=[CH:19][C:18]=1[O:26][CH2:27][C:28]([F:29])([F:31])[F:30]

Participants

3

Reactant 2

HCID 44717685[4-Fluoro-3-(2,2,2-trifluoroethoxy)phenyl]boronic acidHCID 904081442-(5-Bromo-1-methylimidazol-4-yl)pyridine-4-carbonitrile

Product 1

HCID 90407303HCID 90407303, compound

Procedure

The title compound was prepared from 2-(5-bromo-1-methyl-1H-imidazol-4-yl)pyridine-4-carbonitrile (PREPARATION 2) and 4-fluoro-3-(2,2,2-trifluoroethoxy)phenyl boronic acid according to the procedure for the preparation of Example 3, part A. [M+H] Calc'd for C18H12F4N4O, 377. Found, 377.

Sources & evidence

ORD record
ord-e0e67640ebf442108b13bbc95fb01c9e
Source dataset
uspto-grants-2015_09
Patent number
US09133166B2

Reaction notes

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