[4-Fluoro-3-(phenylcarbamoyl)phenyl]boronic acid → HCID 90407652, compound

HRID 2277568Notes

Reaction equation

HRID 2277568 reaction equation
Br[C:2]1[N:6]([CH3:7])[CH:5]=[N:4][C:3]=1[C:8]1[CH:13]=[C:12]([C:14]#[N:15])[CH:11]=[CH:10][N:9]=1.[F:16][C:17]1[CH:22]=[CH:21][C:20](B(O)O)=[CH:19][C:18]=1[C:26](=[O:34])[NH:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[C:14]([C:12]1[CH:11]=[CH:10][N:9]=[C:8]([C:3]2[N:4]=[CH:5][N:6]([CH3:7])[C:2]=2[C:20]2[CH:21]=[CH:22][C:17]([F:16])=[C:18]([CH:19]=2)[C:26]([NH:27][C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)=[O:34])[CH:13]=1)#[N:15]

Participants

3

Reactant 2

HCID 44717533[4-Fluoro-3-(phenylcarbamoyl)phenyl]boronic acidHCID 904081442-(5-Bromo-1-methylimidazol-4-yl)pyridine-4-carbonitrile

Product 1

HCID 90407652HCID 90407652, compound

Procedure

The title compound was prepared from 2-(5-bromo-1-methyl-1H-imidazol-4-yl)pyridine-4-carbonitrile (PREPARATION 2) and 4-fluoro-3-(phenyl carbamoyl)phenyl boronic acid according to the procedure for the preparation of Example 3, part A. [M+H] Calc'd for C23H16FN5O, 398. Found, 398.

Sources & evidence

ORD record
ord-a6954a3fe2ab43c2a1fcee0a0e225b11
Source dataset
uspto-grants-2015_09
Patent number
US09133166B2

Reaction notes

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