反应详情

To 3-benzoylthiophene-2-carboxylic acid (1.00 g, 4.31 mmol) and EtOH (15 mL) was added hydrazine (1.35 ml, 43.1 mmol). A water condenser was attached to the reaction flask and the mixture was heated to reflux under nitrogen for 3.5 hours. The reaction was cooled to RT, the resulting solids filtered and washed with water, and dried to yield 4-phenylthieno[2,3-d]pyridazin-7(6H)-one as a white solid. MS m/z=229 [M+1]+. Calc'd for C12H8N2OS: 228.27.

1. customA water condenser was attached to the reaction flask
2. temperaturethe mixture was heated
3. temperatureto reflux under nitrogen for 3.5 hours
4. filtrationthe resulting solids filtered
5. washwashed with water
6. customdried