2-Methylimidazole → 3-Bromo-5-(2-methyl-imidazol-1-ylmethyl)-pyridine

HRID 2277642Notes

Reaction equation

HRID 2277642 reaction equation
[CH3:1][C:2]1[NH:3][CH:4]=[CH:5][N:6]=1.[Br:7][C:8]1[CH:9]=[N:10][CH:11]=[C:12]([CH2:14]Cl)[CH:13]=1>>[Br:7][C:8]1[CH:9]=[N:10][CH:11]=[C:12]([CH2:14][N:3]2[CH:4]=[CH:5][N:6]=[C:2]2[CH3:1])[CH:13]=1

Participants

3

Reactant 2

HCID 127492-MethylimidazoleHCID 117012593-Bromo-5-(chloromethyl)pyridine

Product 1

HCID 234449653-Bromo-5-(2-methyl-imidazol-1-ylmethyl)-pyridine

Procedure

In analogy to the procedure described for the preparation of intermediates B-1 [B], 2-methyl-imidazol has been coupled to 3-bromo-5-chloromethyl-pyridine (intermediate B-1 [A]) to yield the title compound as a light brown solid. MS: 251.9, 254.0 (M+H+).

Sources & evidence

ORD record
ord-550e98df5fed4254a0526d8c78230d41
Source dataset
uspto-grants-2015_09
Patent number
US09133158B2

Reaction notes

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