N,N'-Dimethylethylenediamine → HCID 86679116, compound

Participants

Reaction Conditions

Reaction Steps

In a sealed tube, 3,5-dibromopyridine (0.5 g, 2.11 mmol) was combined with (S)-5-(hydroxymethyl)pyrrolidin-2-one (0.243 g, 2.11 mmol), copper (I) iodide (0.040 g, 0.021 mmol), potassium carbonate (0.583 g, 4.22 mmol) and N,N′-dimethylethylenediamine (0.037 g, 0.042 mmol) in 1,4-dioxane (20 mL). The reaction mixture was heated at 110° C. overnight. The mixture was cooled to room temperature, filtered through dicalite and washed with DCM. The residue was purified by silica gel flash chromatography eluting with a 0 to 10% MeOH-DCM gradient to give the title compound (0.140 g, 25%) as a light yellow oil. MS: 271.1, 273.1 (M+H+).

Provenance & Evidence