Methyl L-prolinate → HCID 86679124, compound

HRID 2277659Notes

Reaction equation

HRID 2277659 reaction equation
[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][CH2:8][CH2:7][NH:6]1)=[O:4].[Br:10][C:11]1[CH:12]=[N:13][CH:14]=[C:15]([CH2:17]Cl)[CH:16]=1>>[CH3:1][O:2][C:3]([C@@H:5]1[CH2:9][CH2:8][CH2:7][N:6]1[CH2:17][C:15]1[CH:14]=[N:13][CH:12]=[C:11]([Br:10])[CH:16]=1)=[O:4]

Participants

3

Reactant 2

HCID 853477Methyl L-prolinateHCID 117012593-Bromo-5-(chloromethyl)pyridine

Product 1

HCID 86679124HCID 86679124, compound

Procedure

In analogy to the procedure described for the preparation of intermediates B-1 [B], (S)-pyrrolidine-2-carboxylic acid methyl ester has been coupled to 3-bromo-5-chloromethyl-pyridine (intermediate B-1 [A]) to yield the title compound as light yellow oil. MS: 299.2, 301.1 (M+H+).

Sources & evidence

ORD record
ord-5c62e7c73e304053ae9ef4917c07d31a
Source dataset
uspto-grants-2015_09
Patent number
US09133158B2

Reaction notes

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