Hydrochloric Acid → HCID 86685960, compound

Participants

Reaction Steps

To a solution of 2-{5-[(S)-2-(tert-butyl-dimethyl-silanyloxymethyl)-pyrrolidin-1-yl]-pyridin-3-yl}-6-chloro-3,4-dihydro-2H-isoquinolin-1-one (0.110 g, 0.233 mmol) in MeOH (2 mL) was added 4M HCl in dioxane (0.233 ml, 0.932 mmol) and the reaction mixture was stirred at room temperature for 2 h. The mixture was evaporated to dryness, the residue was diluted with DCM (20 mL) and washed with NaHCO3 (10 mL). The organic layer was dried over Na2SO4, filtered and evaporated to dryness. The residue was purified by silica gel flash chromatography eluting with a 0 to 5% MeOH (1% NH4OH)-DCM gradient to give the title compound (0.06 g, 72%) as a light yellow solid. MS: 358.0 (M+H+).

Provenance & Evidence