HCID 86685968, compound → HCID 178493743, compound

Participants

Reaction Conditions

Reaction Steps

2-Methoxy-6-(5-methoxy-pyridin-3-yl)-7,8-dihydro-6H-[1,6]naphthyridin-5one (445 mg, 1.56 mmol) (example 97) was suspended in 2 mL of aq. conc. HCl in 1,4-dioxane (2:1) and heated at 80° C. for 3 hours before the solvent was removed in vacuo. After extraction between EtOAc and H2O, the organic layer was washed with aq. satd. NaHCO3 solution, brine, dried over anhy. Na2SO4, filtered and concentrated in vacuo to give a crude product which was purified by prep-HPLC to yield the title compound (4.9 mg) as a white solid. MS: 270.2 (M+H+).

Provenance & Evidence