Cyclohexyl isocyanate → HCID 86685980, compound

Participants

Reaction Steps

2-(5-Amino-pyridin-3-yl)-6-chloro-3,4-dihydro-2H-isoquinolin-1-one (27.3 mg, 0.1 mmol, example 17) was added to a solution of isocyanato-cyclohexane (12.5 mg, 0.1 mmol) in DCM (2 mL). The reaction mixture was stirred at RT for 2 hours. After evaporation of solvent under reduced pressure, a crude product was obtained which was purified by prep-HPLC to give title compound as a white solid (8.0 mg, 20%). MS: 399.2 (M+H+).

Provenance & Evidence