HCID 86685982, compound → HCID 86685981, compound

Participants

Reaction Steps

6-Chloro-2-(5-methoxy-pyridin-3-yl)-3,4-dihydro-2H-isoquinolin-1-one (1.44 g, 5 mmol, example 10) was dissolved in aq. HBr (48%, 20 mL). The reaction mixture was heated to reflux temperature and stirred overnight. After cooling to room temperature, it was carefully neutralized with satd. aq. NaHCO3 solution and extracted with EtOAc (2×25 mL). The organic layer was dried over anhy. Na2SO4, filtered and concentrated in vacuo to give a crude product (1.02 g, 74%) as brown oil. MS: 275.1 (M+H+).

Provenance & Evidence