Thionyl Chloride → HCID 67153934, compound

HRID 2277694Notes

Reaction equation

HRID 2277694 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8](O)[CH3:9])[CH:5]=[N:6][CH:7]=1.S(Cl)([Cl:13])=O>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[N:6][CH:5]=[C:4]([CH:8]([Cl:13])[CH3:9])[CH:3]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 129974353-Bromo-5-(1-hydroxyethyl)pyridine

Product 1

HCID 67153934HCID 67153934, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1-(5-bromo-pyridine-3-yl)-ethanol (201 mg, 1 mmol) in DCM (10 mL) was added dropwise thionyl chloride (200 uL). The resulting reaction mixture was heated to reflux for 3 hours before the solvent was removed in vacuo to give a crude product as a white solid. It was used directly in the next step without further purification.

Workup

  1. customThe resulting reaction mixture
  2. temperaturewas heated
  3. temperatureto reflux for 3 hours before the solvent
  4. customwas removed in vacuo

Sources & evidence

ORD record
ord-c27f458b268646ceaf04fb6233c8e0a4
Source dataset
uspto-grants-2015_09
Patent number
US09133158B2

Reaction notes

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