HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 86686005, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Methylpicolinic acid | HCID 268757 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 86686004 | HCID 86686004 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 86686005 | HCID 86686005 | 24% |
Reaction Steps
To solution of 2-(5-aminomethyl-pyridin-3-yl)-5-chloro-3,3-dimethyl-2,3-dihydro-isoindol-1-one (30 mg, 0.1 mmol), Et3N (15.3 mg, 0.15 mmol) and 3-methyl-pyridine-2-carboxylic acid (13.7 mg, 0.1 mmol) in DMF (3 mL) was added HATU (57.0 mg, 0.15 mmol) at room temperature. The reaction mixture was stirred at room temperature for 1 hour. Both water and EtOAc were added and the organic layer was dried over anhy. Na2SO4, filtered and concentrated in vacuo to give a residue which was then purified by Prep HPLC to give the title compound (10 mg, 24%) as a solid. MS: 421.2 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133158B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-042015887ce44ed3bbad55f7787b9279 |
| Source note | uspto-grants-2015_09 |