Potassium Phosphate, Tribasic → HCID 86686006, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-chloro-3,3-dimethyl-2,3-dihydro-isoindol-1-one (intermediate A-12) (390 mg, 2 mmol), 3,5-diiodo-pyridine (662 mg, 2 mmol), CuI (38 mg, 0.2 mmol), (1S,2S)-cyclohexane-1,2-diamine (45 mg, 0.4 mmol) and K3PO4 (888 mg, 4 mmol) were dissolved in dioxane (10 mL). The reaction mixture was heated at 110° C. for 3 hours before it was poured into H2O (50 mL) and extracted with EtOAc (25 mL×2). The combined organic layers were washed with brine, dried over anhy. Na2SO4, filtered and concentrated in vacuo to give a crude product which was then purified by silica gel flash chromatography (30-100% EtOAc-hexane gradient) to yield the title compound (495 mg, 62%) as a white solid. MS: 399.0 (M+H+).

Provenance & Evidence