HCID 71743949, compound → HCID 86686010, compound

HRID 2277717Notes

Reaction equation

HRID 2277717 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[NH:6][C:5]2([CH3:13])[CH3:12].Br[C:15]1[CH:16]=[N:17][CH:18]=[C:19]([N:21]2[CH2:25][CH2:24][C@H:23]([O:26][Si](C(C)(C)C)(C)C)[CH2:22]2)[CH:20]=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[N:6]([C:15]1[CH:16]=[N:17][CH:18]=[C:19]([N:21]3[CH2:25][CH2:24][C@H:23]([OH:26])[CH2:22]3)[CH:20]=1)[C:5]2([CH3:13])[CH3:12]

Participants

3

Reactant 2

HCID 71743949HCID 71743949, compoundHCID 86686011Pyridine, 3-bromo-5-[(3S)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-pyrrolidinyl]-

Product 1

HCID 86686010HCID 86686010, compound

Procedure

In analogy to the procedure described for the preparation of example 137, 5-chloro-3,3-dimethyl-2,3-dihydro-isoindol-1-one (intermediate A-12), 3-bromo-5-[(S)-3-(tert-butyl-dimethyl-silanyloxy)-pyrrolidin-1-yl]-pyridine was used (step C) to yield the title compound as a white solid. MS: 358.1 (M+H+).

Sources & evidence

ORD record
ord-f198f908841d4299bebb6de9e28c239f
Source dataset
uspto-grants-2015_09
Patent number
US09133158B2

Reaction notes

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