HCID 86686019, compound → 2-Chloro-6-(N-Boc-piperidin-3-yl)pyrazine

Participants

Reaction Steps

A solution of 3-(6-chloro-pyrazin-2-yl)-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester (46 g) in o-xylene (300 mL) and DMA (30 mL) was heated under reflux for 5 hrs. After cooling to room temperature, it was washed with brine (200 mL×2). The organic layer was then dried over anhy. Na2SO4, filtered, and concentrated in vacuo. The residue obtained was then purified on a silica gel column eluting with EA:DCM:Hex=1:1:3 to give the title compound (18 g) as a white solid. MS: 298.7 (M+H+).

Provenance & Evidence