Acetyl chloride → HCID 86686022, compound

Participants

Reaction Steps

To a mixture of 5-chloro-3,3-dimethyl-2-(6-piperidin-3-yl-pyrazin-2-yl)-2,3-dihydro-isoindol-1-one (80 mg, 0.22 mmol) and Et3N (44.4 mg, 0.44 mmol) in DCM (2 mL) was added acetyl chloride (26.4 mg, 0.34 mmol) at 0° C. After removal of solvent, the residue was purified by prep-HPLC to yield the title compound (30.6 mg, 35%) as a white solid. MS: 399.2 (M+H+).

Provenance & Evidence