Hydrochloric Acid → HCID 86686025, compound

Participants

Reaction Steps

To a solution of 5-chloro-2-(5,5-dimethyl-6′,7′-dihydro-5′H-spiro[1,3-dioxane-2,8′-isoquinolin]-4′-yl)-3,3-dimethyl-2,3-dihydro-1H-isoindol-1-one (0.66 g, 1.55 mmol) in MeOH (2 mL) was added 4 N HCl in dioxane (1.5 mL, 6 mmol) and the reaction mixture was stirred at room temperature for 2 hours. After evaporation of the solvent, the residue was diluted with DCM (20 mL) and washed with satd. aq. NaHCO3 (10 mL) solution. The organic layer was dried over anhy. Na2SO4, filtered and evaporated to dryness. The residue obtained was purified by silica gel flash chromatography eluting with a 0 to 50% hexane-ethyl acetate gradient to give the title compound (421 mg, 80%) as a light yellow solid. MS: 341.1 (M+H+).

Provenance & Evidence