反应详情

Sodium methanethiolate (13.5 g; 192 mmol) was added in two portions to a stirred solution of 1-(chloromethyl)-3-nitrobenzene (30.0 g; 175 mmol; Aldrich Chemical Company Inc.) in ethanol (360 mL) at −15° C. The cold bath was removed and the batch was stirred at room temperature for 3 hours. The batch was diluted with saturated aqueous sodium chloride solution and extracted with ethyl acetate (2×). The combined organic phases were washed with water, dried (sodium sulfate), filtered and concentrated to give the desired product (32.2 g) that was used without further purification.

1. customThe cold bath was removed
2. additionThe batch was diluted with saturated aqueous sodium chloride solution
3. extractionextracted with ethyl acetate (2×)
4. washThe combined organic phases were washed with water
5. dry with materialdried (sodium sulfate)
6. filtrationfiltered
7. concentrationconcentrated