HCID 81149778, compound → HCID 89444489, compound

HRID 2277756Notes

Reaction equation

HRID 2277756 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:9]=2[O:15][CH3:16])[C:5]([F:17])=[CH:4][N:3]=1.[CH3:18][O:19][C:20]1[CH:21]=[C:22]([CH:24]=[C:25]([CH2:27][S:28][CH3:29])[CH:26]=1)[NH2:23]>>[F:17][C:5]1[C:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:9]=2[O:15][CH3:16])=[N:7][C:2]([NH:23][C:22]2[CH:24]=[C:25]([CH2:27][S:28][CH3:29])[CH:26]=[C:20]([O:19][CH3:18])[CH:21]=2)=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 81149778HCID 81149778, compoundHCID 867296092-Chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidine

Product 1

HCID 89444489HCID 89444489, compound

Procedure

Intermediate 32.3 was prepared under similar conditions as described in the preparation of Intermediate 20.1 using 2-chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidine and 3-methoxy-5-[(methyl-sulfanyl)methyl]aniline. The batch was purified by chromatography (hexane to hexane/ethyl acetate 7:3) to give the desired product.

Workup

  1. customThe batch was purified by chromatography (hexane to hexane/ethyl acetate 7:3)

Sources & evidence

ORD record
ord-7af1a94f7de945bb85e716c4fc1ea105
Source dataset
uspto-grants-2015_09
Patent number
US09133171B2

Reaction notes

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