HCID 89239810, compound → HCID 89444595, compound

HRID 2277757Notes

Reaction equation

HRID 2277757 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:9]=2[O:15][CH2:16][CH3:17])[C:5]([F:18])=[CH:4][N:3]=1.[F:19][C:20]1[CH:21]=[C:22]([CH:24]=[C:25]([CH2:27][S:28][CH3:29])[CH:26]=1)[NH2:23]>>[CH2:16]([O:15][C:9]1[CH:10]=[C:11]([F:14])[CH:12]=[CH:13][C:8]=1[C:6]1[C:5]([F:18])=[CH:4][N:3]=[C:2]([NH:23][C:22]2[CH:24]=[C:25]([CH2:27][S:28][CH3:29])[CH:26]=[C:20]([F:19])[CH:21]=2)[N:7]=1)[CH3:17]

Participants

3

Reactant 2

HCID 89239810HCID 89239810, compoundHCID 89444754HCID 89444754, compound

Product 1

HCID 89444595HCID 89444595, compound

Procedure

Intermediate 36.2 was prepared under similar conditions as described in the preparation of Intermediate 20.1 using 2-chloro-4-(2-ethoxy-4-fluorophenyl)-5-fluoropyrimidine and 3-fluoro-5-[(methylsulfanyl)-methyl]aniline. The residue was purified by chromatography (hexane to hexane/ethyl acetate 7:3) to give the desired product.

Workup

  1. customThe residue was purified by chromatography (hexane to hexane/ethyl acetate 7:3)

Sources & evidence

ORD record
ord-d9d249c73db14988b565b22a4254e48a
Source dataset
uspto-grants-2015_09
Patent number
US09133171B2

Reaction notes

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