2-Chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidine → HCID 89444404, compound

HRID 2277759Notes

Reaction equation

HRID 2277759 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:9]=2[O:15][CH3:16])[C:5]([F:17])=[CH:4][N:3]=1.[CH3:18][S:19][CH2:20][C:21]1[CH:22]=[C:23]([CH:25]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:27]=1)[NH2:24]>>[F:17][C:5]1[C:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:9]=2[O:15][CH3:16])=[N:7][C:2]([NH:24][C:23]2[CH:25]=[C:26]([C:28]([F:29])([F:30])[F:31])[CH:27]=[C:21]([CH2:20][S:19][CH3:18])[CH:22]=2)=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 867296092-Chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidineHCID 89444390HCID 89444390, compound

Product 1

HCID 89444404HCID 89444404, compound

Procedure

Intermediate 40.3 was prepared under similar conditions as described in the preparation of Intermediate 20.1 using 2-chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidine and 3-[(methylsulfanyl)methyl]-5-(trifluoromethyl)aniline. The residue was purified by chromatography (hexane to hexane/ethyl acetate 15%) to give the desired product.

Workup

  1. customThe residue was purified by chromatography (hexane to hexane/ethyl acetate 15%)

Sources & evidence

ORD record
ord-94730bff4e96408089564e8838d2c9ed
Source dataset
uspto-grants-2015_09
Patent number
US09133171B2

Reaction notes

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