2-Chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidine → HCID 89444136, compound

HRID 2277760Notes

Reaction equation

HRID 2277760 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:9]=2[O:15][CH3:16])[C:5]([F:17])=[CH:4][N:3]=1.[CH2:18]([S:20][CH2:21][C:22]1[CH:23]=[C:24]([CH:26]=[C:27]([F:29])[CH:28]=1)[NH2:25])[CH3:19]>>[CH2:18]([S:20][CH2:21][C:22]1[CH:23]=[C:24]([NH:25][C:2]2[N:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:9]=3[O:15][CH3:16])[C:5]([F:17])=[CH:4][N:3]=2)[CH:26]=[C:27]([F:29])[CH:28]=1)[CH3:19]

Participants

3

Reactant 2

HCID 867296092-Chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidineHCID 89444607HCID 89444607, compound

Product 1

HCID 89444136HCID 89444136, compound

Procedure

Intermediate 42.3 was prepared under similar conditions as described in the preparation of Intermediate 20.1 using 2-chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidine and 3-[(ethylsulfanyl)methyl]-5-fluoroaniline. The batch was purified by chromatography (hexane to hexane/ethyl acetate 30%) to give the desired product.

Workup

  1. customThe batch was purified by chromatography (hexane to hexane/ethyl acetate 30%)

Sources & evidence

ORD record
ord-3a5fcee99cb14dc99dbcf6cd034a7155
Source dataset
uspto-grants-2015_09
Patent number
US09133171B2

Reaction notes

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