2-Chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidine → HCID 89444772, compound

HRID 2277761Notes

Reaction equation

HRID 2277761 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:9]=2[O:15][CH3:16])[C:5]([F:17])=[CH:4][N:3]=1.[NH2:18][C:19]1[CH:20]=[C:21]([CH2:32][OH:33])[CH:22]=[C:23]([C:25]([F:31])([F:30])[C:26]([F:29])([F:28])[F:27])[CH:24]=1>>[F:17][C:5]1[C:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:9]=2[O:15][CH3:16])=[N:7][C:2]([NH:18][C:19]2[CH:20]=[C:21]([CH2:32][OH:33])[CH:22]=[C:23]([C:25]([F:30])([F:31])[C:26]([F:27])([F:28])[F:29])[CH:24]=2)=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 867296092-Chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidineHCID 89444642HCID 89444642, compound

Product 1

HCID 89444772HCID 89444772, compound

Procedure

Intermediate 46.3 was prepared under similar conditions as described in the preparation of Intermediate 20.1 using 2-chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidine and [3-amino-5-(pentafluoro-ethyl)phenyl]methanol. The residue was purified by chromatography (hexane/ethyl acetate 6:4) to give the desired product.

Workup

  1. customThe residue was purified by chromatography (hexane/ethyl acetate 6:4)

Sources & evidence

ORD record
ord-85f82e95ab344a3dadb48fd1587aaddc
Source dataset
uspto-grants-2015_09
Patent number
US09133171B2

Reaction notes

Loading…