2-Chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidine → HCID 89444778, compound

HRID 2277765Notes

Reaction equation

HRID 2277765 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:9]=2[O:15][CH3:16])[C:5]([F:17])=[CH:4][N:3]=1.[Cl:18][C:19]1[CH:20]=[C:21]([CH:23]=[C:24]([CH2:26][S:27][CH3:28])[CH:25]=1)[NH2:22]>>[Cl:18][C:19]1[CH:20]=[C:21]([NH:22][C:2]2[N:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:9]=3[O:15][CH3:16])[C:5]([F:17])=[CH:4][N:3]=2)[CH:23]=[C:24]([CH2:26][S:27][CH3:28])[CH:25]=1

Participants

3

Reactant 2

HCID 867296092-Chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidineHCID 89444276HCID 89444276, compound

Product 1

HCID 89444778HCID 89444778, compound

Procedure

Intermediate 56.5 was prepared under similar conditions as described in the preparation of Intermediate 28.3 using 2-chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyrimidine and 3-chloro-5-[(methylsulfanyl)-methyl]aniline. The batch was purified by chromatography (hexane to hexane/ethyl acetate 30%) to give the desired product.

Workup

  1. customThe batch was purified by chromatography (hexane to hexane/ethyl acetate 30%)

Sources & evidence

ORD record
ord-2c3dcab1bd87468bab04ecfad9bc5fe9
Source dataset
uspto-grants-2015_09
Patent number
US09133171B2

Reaction notes

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