Formic Acid → HCID 86728492, compound

Participants

Reaction Steps

After cooling the reaction mixture to room temperature, a solution of triethylamine (670 μL, 4.9 mmol) and formic acid (150 μL, 4.0 mmol) in 2-propanol (1.1 mL) and 20% Pd(OH)2 carbon (19 mg; water content: 50%) were added, and after warming to 50° C., the mixture was stirred for 4.5 hours. The reaction mixture was subjected to HPLC analysis under the same conditions as HPLC conditions (2) of Example 10, and the purities of the title compound and its precursor (2-[(2-acetylamino-5-chloro-3-fluoropyridin-4-yl)methyl]-3-oxobutanoic acid ethyl ester) were calculated from their respective area ratios.

Provenance & Evidence