反应详情

To a stirring solution of bis(4-bromophenyl)methanol (0.060 mmol) in CH2Cl2 (0.3 mL) was added thionyl chloride (40 μL, 0.60 mmol) and the reaction mixture was stirred for 48 h. The reaction was evaporated to dryness under a stream of N2 and the crude product redissolved in acetonitrile (1.0 mL). 1-Boc-piperazine (22.3 mg, 0.12 mmol) was added and the reaction mixture was refluxed for 4 h. The reaction mixture was concentrated under reduced pressure, redissolved in CH2Cl2 and passed through a short pad of SiO2, providing the 1-Boc-4-diphenylmethylpiperazine.

1. customThe reaction was evaporated to dryness under a stream of N2
2. dissolutionthe crude product redissolved in acetonitrile (1.0 mL)
3. temperaturethe reaction mixture was refluxed for 4 h
4. concentrationThe reaction mixture was concentrated under reduced pressure
5. dissolutionredissolved in CH2Cl2