(3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine → HCID 89682761, compound

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Reaction Steps

The title compound was prepared from 4-chloro-2-fluoro-benzaldehyde and (R)-tert-butyl pyrrolidin-3-ylcarbamate as described in Example 70, Step 1 (30.0 mg, 81%). 1H NMR 400 MHz (CDCl3) δ 9.98 (s, 1H), 7.63 (d, J=8.3 Hz, 1H), 6.89-6.79 (m, 2H), 4.77 (s, 1H), 3.57 (dd, J=10.7, 6.0 Hz, 2H), 3.34 (s, 1H), 3.25-3.18 (m, 1H), 2.28 (td, J=12.9, 7.0 Hz, 1H), 2.00 (td, J=12.5, 6.4 Hz, 2H), 1.46 (s, 9H). LCMS (ESI, an/z): 325 [M+H]+.

Provenance & Evidence