Sodium 1-Methyl 3-Sulfinopropionate → HCID 89526185, compound

Participants

Reaction Conditions

Reaction Steps

5-bromo-1-(propan-2-ylsulfonyl)-1H-indazole (0.85 g, 2.79 mmol), sodium 3-methoxy-3-oxopropane-1-sulfinate (2.42 g, 13.9 mmol) and CuI (2.66 g, 13.9 mmol) were charged in a sealable microwave flask. The flask was closed and degassed twice, after which dry DMSO (3.0 mL) was added and the reaction mixture degassed before being heated at 110° C. in an oil bath overnight. The reaction mixture was cooled and diluted with ethyl acetate (40 mL), and then filtered on a silica gel pad and eluted with ethyl acetate. The organic phases were concentrated under reduced pressure. The crude was purified on silica gel eluting with hexanes and ethyl acetate, then with DCM and methanol to afford the title compound.

Provenance & Evidence