Sodium borohydride → HCID 89525739, compound

Participants

Reaction Steps

N-[2-{[tert-butyl(dimethyl)silyl]oxy}-1-(4-{[(tert-butylsulfinyl)imino]methyl}thiophen-2-yl)ethyl]-N-(3-methylbutyl)benzenesulfonamide (146 mg, 0.244 mmol) was dissolved in 2.4 mL MeOH at −78° C. Sodium borohydride (11.99 mg, 0.317 mmol) was added and the mixture was then warmed to room temperature and stirred for 1 hour. The reaction was quenched slowly with saturated NaHCO3, after which DCM was added and the phases separated with a phase extractor. The DCM was removed under reduced pressure.

Provenance & Evidence