Nitric Acid → 2-Bromo-1,3-dimethyl-4-nitrobenzene

Participants

Reaction Steps

Fuming nitric acid (32.5 ml) was slowly added to a solution of 2,6-dimethyl-bromobenzene (10 g, 54 mmol) in AcOH (75 ml) cooled in an ice bath. The resulting mixture was allowed to warm to room temperature, stirred for 1 h, and heated at 80° C. for 2 h. The reaction mixture was cooled to room temperature and poured into ice water with stirring. The resultant precipitate was collected by suction filtration to afford the title compound (10 g) which was used without further purification.

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