3-Methyl-2-nitrophenol → 4-Bromo-3-methyl-2-nitrophenol

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-methyl-2-nitro-phenol (20 g, 0.13 mol) in CHCl3 (20 mL) was added a solution of Br2 (6.4 mL) in HOAc (15 mL) dropwise at 0° C. and the mixture was stirred at 0° C. for 3 h. Ice was added and the mixture was extracted with CHCl3. After drying over Na2SO4, CHCl3 was removed to give 4-bromo-3-methyl-2-nitro-phenol (30 g) which was used without further purification.

Provenance & Evidence