Potassium Nitrate → 1-Bromo-4-fluoro-2-methyl-5-nitrobenzene

Participants

Reaction Steps

To a solution of 1-bromo-4-fluoro-2-methyl-benzene (20 g, 0.11 mol) in 160 mL H2SO4 was added KNO3 (116 g, 0.11 mol) in one portion at 0° C. The mixture was allowed to warm to rt and stirred overnight. The mixture was poured into ice water, extracted with EtOAc, dried over Na2SO4 and concentrated to give 1-bromo-4-fluoro-2-methyl-5-nitro-benzene (20 g) which was used in the subsequent reaction without purification.

Provenance & Evidence