HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hydroxybenzotriazole → HCID 89739155, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 89739213 | HCID 89739213 | — |
| Solvent | Ammonia | HCID 222 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 89739155 | HCID 89739155 | — |
Reaction Steps
A mixture of 4-{4-[4-carboxy-2-(7-trifluoromethyl-1H-indol-4-yl)-oxazol-5-yl]-phenyl}-2,2-dimethyl-piperazine-1-carboxylic acid tert-butyl ester, EDCI HCl (0.36 g, 0.002 mol) and HOBt (0.3 g, 0.002 mol) in 15 mL of DMF and 15 mL of NH3 in dioxane was stirred for 2 hrs. The solvents were removed in vacuo. The residue was partitioned between water and EtOAc, the organic phase dried over Na2SO4 and the solvent removed in vacuo to give the crude title compound product (0.18 g crude).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09133180B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-5ce981ad68cf4a84857e967d27e743e3 |
| Source note | uspto-grants-2015_09 |