2,6-Dimethylmorpholine, cis- → HCID 69088090, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-bromo-2-chloro-4-methoxypyrimidine (17.2 g, 77 mmol) stirred in air at 0° C. was added neat cis-2,6-dimethylmorpholine (24.5 g, 213 mmol) dropwise in 10 minutes. The reaction mixture was stirred at 45° C. for 30 minutes. The organic phase was evaporated in vacuo to give the crude product as a white solid. The crude product was added to a silica gel column and was eluted with hexane/ethyl acetate (20/1). Collected fractions were evaporated to give the title compound as white solid (17.4 g, 49.3 mmol, 64.1% yield). LC/MS [M+H]+=302/304.

Provenance & Evidence