Hydrochloric Acid → HCID 67513141, compound

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A solution of 4-(2-methyl-3-furanyl)-2-(3-methyl-1-piperidinyl)-5-(2-pyridinyl)pyrimidine (200 mg, 0.6 mmol) in dichloromethane (2 ml) was treated with hydrogen chloride (1M in diethyl ether, 0.8 ml). The solvent was evaporated and the residue co-evaporated with dichloromethane (×2). The resulting solid was dried to give the title compound as a pale yellow solid (160 mg, 43%). LC/MS [M+H]+=335. 1H NMR (400 MHz, d6-DMSO): δ 8.77 (1H, d), 8.56 (1H, s), 8.25-8.21 (1H, m), 7.74-7.65 (2H, m), 7.45 (1H, d), 7.78 (1H, d), 4.66-4.60 (2H, m), 3.12-2.98 (1H, m), 2.75-2.66 (1H, m), 2.40 (3H, s), 1.90-1.20 (5H, m), 0.93 (3H, d).

Provenance & Evidence