2-Methylindoline → HCID 68281780, compound

Participants

Reaction Steps

The product is prepared by following the procedure described in example 1a (step 5a) using 600 mg of sodium (5-fluoro-4-methoxy-6-morpholin-4-ylpyrimidin-2-yl)acetate obtained in example 1a (step 4a) and 272 mg of 2-methyl-2,3-dihydro-1H-indole. After purification by silica column chromatography (eluent: 97/03 dichloromethane/ethyl acetate), 366 mg of 2-(5-fluoro-4-methoxy-6-morpholin-4-ylpyrimidin-2-yl)-1-(2-methyl-2,3-dihydroindol-1-yl) ethanone are obtained in the form of a white powder, the characteristics of which are the following:

Provenance & Evidence