Ethanol → HCID 136238744, compound

Participants

Reaction Steps

20 ml of ethanol, 1.5 g of 2-methylmorpholine, 8.7 g of ethyl 3-ethoxy-3-iminopropanoate hydrochloride and 7.75 ml of N,N-diisopropylethylamine are placed in a microwave tube. After one hour of microwave irradiation at a temperature of 130° C., the reaction medium is concentrated under reduced pressure. The residue obtained is purified on a silica column, eluent: dichloromethane/methanol: 97/03, so as to give 0.8 g of [4-(2-methylmorpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetic acid ethyl ester in the form of a beige solid, the characteristics of which are the following:

Provenance & Evidence