Water → 2-[2-(4-fluoro-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-(2-methylmorpholin-4-yl)-3H-pyrimidin-4-one

HRID 2278533Notes

Reaction equation

HRID 2278533 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][N:6]2[C:11](=[O:21])[CH2:12][C:13]1[NH:18][C:17](=[O:19])[CH:16]=[C:15](Cl)[N:14]=1.[OH2:22]>CC1OCCNC1>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][N:6]2[C:11](=[O:21])[CH2:12][C:13]1[NH:18][C:17](=[O:19])[CH:16]=[C:15]([N:6]2[CH2:7][CH2:8][O:22][CH:4]([CH3:3])[CH2:5]2)[N:14]=1

Participants

4

Reactant 2

HCID 962WaterHCID 1363786742-[2-(4-fluoro-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-chloro-3H-pyrimidin-4-one

Product 1

HCID 1360984702-[2-(4-fluoro-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-(2-methylmorpholin-4-yl)-3H-pyrimidin-4-one

Reagents, catalysts & solvents 1

HCID 4106152-MethylmorpholineSolvent

Procedure

A solution of 200 mg of 2-[2-(4-fluoro-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-chloro-3H-pyrimidin-4-one in 2 ml of 2-methylmorpholine is heated at 100° C. for 15 minutes. The reaction medium is taken up with 10 ml of water. The solid formed is filtered off and washed with water and then dried so as to give 216 mg of 2-[2-(4-fluoro-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-(2-methylmorpholin-4-yl)-3H-pyrimidin-4-one in the form of a beige solid, the characteristics of which are the following:

Workup

  1. customThe solid formed
  2. filtrationis filtered off
  3. washwashed with water
  4. customdried so as

Sources & evidence

ORD record
ord-b938c3255c2a4eb2bb05c88a9d54d278
Source dataset
uspto-grants-2015_09
Patent number
US09133168B2

Reaction notes

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