Methanol → 2-[2-(4-fluoro-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-pyridin-4-yl-3H-pyrimidin-4-one

Participants

Reaction Steps

In a microwave tube, a mixture of 59 mg of 2-[2-(4-fluoro-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-chloro-3H-pyrimidin-4-one, 88 mg of pyridine-4-boronic acid pinacol ester, 32 mg of tetrakis(triphenylphosphine)palladium and 0.26 ml of a 1.5M cesium carbonate solution in 1.25 ml of dioxane is microwave-irradiated for one and a half hours at 100° C. The reaction medium is taken up with a mixture of methanol, ethyl acetate and a few drops of water. The solid formed is filtered off and washed with water and then dried so as to give 20 mg of 2-[2-(4-fluoro-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-pyridin-4-yl-3H-pyrimidin-4-one in the form of a beige solid, the characteristics of which are the following:

Provenance & Evidence