反应详情

温度

100 °C

33 g of (4-chloro-6-methoxypyrimidin-2-yl)acetic acid ethyl ester (example 8b, step 2b) and 750 ml of acetonitrile are placed in a 1000 ml autoclave and then 71.2 g of potassium iodide and 55.85 ml of trimethylchlorosilane are added; an orangey-colored heterogeneous solution is obtained, which is stirred while heating under an argon pressure of 10 bar at 100° C. for 2 hours. The reaction medium is drawn off, then insoluble material is filtered off, washing is carried out with 3 times approximately 100 ml of EtOAc, and the filtrate is concentrated until a pasty residue is obtained, which is taken up in 500 ml of water. After stirring, extraction is carried out with 3 times approximately 350 ml of ethyl acetate, the combined organic extracts are washed with 500 ml of saturated NaCl solution, drying is carried out over MgSO4, filtration is carried out through a VF filter, and the resulting product is concentrated under vacuum. The compound obtained is purified by chromatography on silica gel (40-63 μm), elution being carried out with a mixture of EtOAc/n-heptane (2/8 v/v). The fractions containing the expected compound are combined and evaporated. A solid is isolated, which is triturated from diisopropyl ether, filtered through sintered glass and dried. (4-Chloro-6-oxo-1,6-dihydropyrimidin-2-yl)acetic acid ethyl ester is isolated in the form of a beige solid: 25.2 g; yield 81%.

1. customan orangey-colored heterogeneous solution is obtained
2. filtrationinsoluble material is filtered off
3. washwashing
4. concentrationthe filtrate is concentrated until a pasty residue
5. customis obtained
6. stirringAfter stirring
7. extractionextraction
8. washthe combined organic extracts are washed with 500 ml of saturated NaCl solution
9. customdrying
10. filtrationis carried out over MgSO4, filtration
11. filtrationfilter
12. concentrationthe resulting product is concentrated under vacuum
13. customThe compound obtained
14. customis purified by chromatography on silica gel (40-63 μm), elution
15. additionbeing carried out with a mixture of EtOAc/n-heptane (2/8 v/v)
16. additionThe fractions containing the expected compound
17. customevaporated
18. customA solid is isolated
19. customwhich is triturated from diisopropyl ether
20. filtrationfiltered through sintered glass
21. customdried