1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 136378683, compound

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Reaction Steps

(±)-2-{2-[4-Hydroxy-3-methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one is prepared by following the procedure described in example 1c using 0.70 g of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 0.44 g of 4-hydroxy-3-methylindoline (reference example 3c), and 0.68 g of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 0.65 ml of pyridine and 15 ml of N,N-dimethylformamide. 0.55 g of (±)-2-{2-[4-hydroxy-3-methyl-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one is thus obtained in the form of a bright pink powder, the characteristics of which are the following:

Provenance & Evidence