1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 136378687, compound

Participants

Reaction Steps

The product is prepared by following the procedure described in example 1c using 0.27 g of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate, 0.15 g of (+)-2-isopropylindoline and 0.24 g of N-[3-(dimethylamino)propyl]-N′-ethylcarbodiimide hydrochloride in a mixture of 0.23 ml of pyridine and 3.8 ml of N,N-dimethylformamide. 0.24 g of (+)-2-[2-(2-isopropyl-2,3-dihydroindol-1-yl)-2-oxoethyl]-6-morpholin-4-yl-3H-pyrimidin-4-one (reference example 12c) is thus obtained in the form of a white solid, the characteristics of which are the following:

Provenance & Evidence