反应详情

1.5 g of (4-chloro-6-methoxypyrimidin-2-yl)acetic acid ethyl ester and 20 ml of morpholine are mixed together in a microwave tube. After microwave irradiation for 1 h at 90° C., the reaction mixture is concentrated under reduced pressure and then diluted with 300 ml of ethyl acetate and 300 ml of water. After settling out, the organic phase is dried over magnesium sulfate, filtered, and then concentrated under reduced pressure. 1.9 g of (4-methoxy-6-morpholin-4-ylpyrimidin-2-yl)acetic acid ethyl ester are thus obtained in the form of a viscous oil which crystallizes and which is used as it is in the next step.

1. customAfter microwave irradiation for 1 h at 90° C.
2. concentrationthe reaction mixture is concentrated under reduced pressure
3. additiondiluted with 300 ml of ethyl acetate and 300 ml of water
4. dry with materialthe organic phase is dried over magnesium sulfate
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure