Hydrochloric Acid → HCID 136641626, compound

Participants

Reaction Steps

17 ml of hydrochloric acid (4M in dioxane) are added to 340 mg of 2-fluoro-1-(4-fluoro-2,3-dihydro-1H-indol-1-yl)-2-[4-methoxy-6-(morpholin-4-yl)pyrimidin-2-yl]propan-1-one, obtained according to the previous step. The reaction medium is stirred at reflux for 5 hours, allowed to return to ambient temperature, and then concentrated under reduced pressure. The residue obtained is purified on a silica column, eluent: 98/02 dichloromethane/methanol, so as to give 236 mg of racemic 2-[2-fluoro-1-(4-fluoro-2,3-dihydro-1H-indol-1-yl)-1-oxopropan-2-yl]-6-(morpholin-4-yl)pyrimidin-4(3H)-one in the form of a white solid which will be used as it is in the next step.

Provenance & Evidence